Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

A next-generation intranasal trivalent MMS vaccine induces durable and broad protection against SARS-CoV-2 variants of concern.

Xu, Jiayu; Zhang, Yuexiu; Qu, Panke; Shamseldin, Mohamed M; Yoo, Sung J; Misny, Jack; Thongpan, Ilada; Kc, Mahesh; Hall, Jesse M; Evans, John P; Eltobgy, Mostafa; Lu, Mijia; Ye, Chengjin; Chamblee, Michelle; Liang, Xueya; Martinez-Sobrido, Luis; Amer, Amal O; Yount, Jacob S; Boyaka, Prosper N; Peeples, Mark E; Liu, Shan-Lu; Dubey, Purnima; Li, Jianrong.

Proc Natl Acad Sci U S A ; 120(41): e2220403120, 2023 10 10.

Artigo em Inglês | MEDLINE | ID: mdl-37796985

2.

Caspase-4/11 exacerbates disease severity in SARS-CoV-2 infection by promoting inflammation and immunothrombosis.

Eltobgy, Mostafa M; Zani, Ashley; Kenney, Adam D; Estfanous, Shady; Kim, Eunsoo; Badr, Asmaa; Carafice, Cierra; Daily, Kylene; Whitham, Owen; Pietrzak, Maciej; Webb, Amy; Kawahara, Jeffrey; Eddy, Adrian C; Denz, Parker; Lu, Mijia; Kc, Mahesh; Peeples, Mark E; Li, Jianrong; Zhu, Jian; Que, Jianwen; Robinson, Richard; Rosas Mejia, Oscar; Rayner, Rachael E; Hall-Stoodley, Luanne; Seveau, Stephanie; Gavrilin, Mikhail A; Zhang, Xiaoli; Thomas, Jeronay; Kohlmeier, Jacob E; Suthar, Mehul S; Oltz, Eugene; Tedeschi, Andrea; Robledo-Avila, Frank H; Partida-Sanchez, Santiago; Hemann, Emily A; Abdelrazik, Eman; Forero, Adriana; Nimjee, Shahid M; Boyaka, Prosper N; Cormet-Boyaka, Estelle; Yount, Jacob S; Amer, Amal O.

Proc Natl Acad Sci U S A ; 119(21): e2202012119, 2022 05 24.

Artigo em Inglês | MEDLINE | ID: mdl-35588457

3.

Inhibition of elastase enhances the adjuvanticity of alum and promotes anti-SARS-CoV-2 systemic and mucosal immunity.

Kim, Eunsoo; Attia, Zayed; Woodfint, Rachel M; Zeng, Cong; Kim, Sun Hee; Steiner, Haley E; Shukla, Rajni Kant; Liyanage, Namal P M; Ghimire, Shristi; Li, Jianrong; Renukaradhya, Gourapura J; Satoskar, Abhay R; Amer, Amal O; Liu, Shan-Lu; Cormet-Boyaka, Estelle; Boyaka, Prosper N.

Proc Natl Acad Sci U S A ; 118(34)2021 08 24.

Artigo em Inglês | MEDLINE | ID: mdl-34353890

4.

Pyroptotic and non-pyroptotic effector functions of caspase-11.

Abu Khweek, Arwa; Amer, Amal O.

Immunol Rev ; 297(1): 39-52, 2020 09.

Artigo em Inglês | MEDLINE | ID: mdl-32737894

5.

Cystic fibrosis macrophage function and clinical outcomes after elexacaftor/tezacaftor/ivacaftor.

Zhang, Shuzhong; Shrestha, Chandra L; Robledo-Avila, Frank; Jaganathan, Devi; Wisniewski, Benjamin L; Brown, Nevian; Pham, Hanh; Carey, Katherine; Amer, Amal O; Hall-Stoodley, Luanne; McCoy, Karen S; Bai, Shasha; Partida-Sanchez, Santiago; Kopp, Benjamin T.

Eur Respir J ; 61(4)2023 04.

Artigo em Inglês | MEDLINE | ID: mdl-36265882

6.

Caspase-11 regulates lung inflammation in response to house dust mites.

Abu Khweek, Arwa; Joldrichsen, Marisa R; Kim, Eunsoo; Attia, Zayed; Krause, Kathrin; Daily, Kylene; Estfanous, Shady; Hamilton, Kaitlin; Badr, Asmaa; Anne, Midhun N K; Eltobgy, Mostafa; Corps, Kara N; Carafice, Cierra; Zhang, Xiaoli; Gavrilin, Mikhail A; Boyaka, Prosper N; Amer, Amal O.

Cell Immunol ; 370: 104425, 2021 12.

Artigo em Inglês | MEDLINE | ID: mdl-34800762

7.

Caspase-11 promotes the fusion of phagosomes harboring pathogenic bacteria with lysosomes by modulating actin polymerization.

Akhter, Anwari; Caution, Kyle; Abu Khweek, Arwa; Tazi, Mia; Abdulrahman, Basant A; Abdelaziz, Dalia H A; Voss, Oliver H; Doseff, Andrea I; Hassan, Hoda; Azad, Abul K; Schlesinger, Larry S; Wewers, Mark D; Gavrilin, Mikhail A; Amer, Amal O.

Immunity ; 37(1): 35-47, 2012 Jul 27.

Artigo em Inglês | MEDLINE | ID: mdl-22658523

8.

Caspase-11 counteracts mitochondrial ROS-mediated clearance of Staphylococcus aureus in macrophages.

Krause, Kathrin; Daily, Kylene; Estfanous, Shady; Hamilton, Kaitlin; Badr, Asmaa; Abu Khweek, Arwa; Hegazi, Rana; Anne, Midhun Nk; Klamer, Brett; Zhang, Xiaoli; Gavrilin, Mikhail A; Pancholi, Vijay; Amer, Amal O.

EMBO Rep ; 20(12): e48109, 2019 12 05.

Artigo em Inglês | MEDLINE | ID: mdl-31637841

9.

The CATERPILLERS.

Amer, Amal O.

J Immunol ; 212(1): 5-6, 2024 01 01.

Artigo em Inglês | MEDLINE | ID: mdl-38118106

10.

COLMAR Lipids Web Server and Ultrahigh-Resolution Methods for Two-Dimensional Nuclear Magnetic Resonance- and Mass Spectrometry-Based Lipidomics.

Wang, Cheng; Timári, István; Zhang, Bo; Li, Da-Wei; Leggett, Abigail; Amer, Amal O; Bruschweiler-Li, Lei; Kopec, Rachel E; Brüschweiler, Rafael.

J Proteome Res ; 19(4): 1674-1683, 2020 04 03.

Artigo em Inglês | MEDLINE | ID: mdl-32073269

11.

Dysregulated Calcium Homeostasis in Cystic Fibrosis Neutrophils Leads to Deficient Antimicrobial Responses.

Robledo-Avila, Frank H; Ruiz-Rosado, Juan de Dios; Brockman, Kenneth L; Kopp, Benjamin T; Amer, Amal O; McCoy, Karen; Bakaletz, Lauren O; Partida-Sanchez, Santiago.

J Immunol ; 201(7): 2016-2027, 2018 10 01.

Artigo em Inglês | MEDLINE | ID: mdl-30120123

12.

The cooperation between the autophagy machinery and the inflammasome to implement an appropriate innate immune response: do they regulate each other?

Abdelaziz, Dalia H A; Khalil, Hany; Cormet-Boyaka, Estelle; Amer, Amal O.

Immunol Rev ; 265(1): 194-204, 2015 May.

Artigo em Inglês | MEDLINE | ID: mdl-25879294

13.

The psychoactive substance of cannabis Δ9-tetrahydrocannabinol (THC) negatively regulates CFTR in airway cells.

Chang, Sheng-Wei; Wellmerling, Jack; Zhang, Xiaoli; Rayner, Rachael E; Osman, Wissam; Mertz, Sara; Amer, Amal O; Peeples, Mark E; Boyaka, Prosper N; Cormet-Boyaka, Estelle.

Biochim Biophys Acta Gen Subj ; 1862(9): 1988-1994, 2018 09.

Artigo em Inglês | MEDLINE | ID: mdl-29928919

14.

TGF-ß-induced IL-6 prevents development of acute lung injury in influenza A virus-infected F508del CFTR-heterozygous mice.

Woods, Parker S; Tazi, Mia F; Chesarino, Nicholas M; Amer, Amal O; Davis, Ian C.

Am J Physiol Lung Cell Mol Physiol ; 308(11): L1136-44, 2015 Jun 01.

Artigo em Inglês | MEDLINE | ID: mdl-25840995

15.

Depletion of the ubiquitin-binding adaptor molecule SQSTM1/p62 from macrophages harboring cftr ΔF508 mutation improves the delivery of Burkholderia cenocepacia to the autophagic machinery.

Abdulrahman, Basant A; Khweek, Arwa Abu; Akhter, Anwari; Caution, Kyle; Tazi, Mia; Hassan, Hoda; Zhang, Yucheng; Rowland, Patrick D; Malhotra, Sankalp; Aeffner, Famke; Davis, Ian C; Valvano, Miguel A; Amer, Amal O.

J Biol Chem ; 288(3): 2049-58, 2013 Jan 18.

Artigo em Inglês | MEDLINE | ID: mdl-23148214

16.

A bacterial protein promotes the recognition of the Legionella pneumophila vacuole by autophagy.

Khweek, Arwa A; Caution, Kyle; Akhter, Anwari; Abdulrahman, Basant A; Tazi, Mia; Hassan, Hoda; Majumdar, Neal; Doran, Andrew; Guirado, Evelyn; Schlesinger, Larry S; Shuman, Howard; Amer, Amal O.

Eur J Immunol ; 43(5): 1333-44, 2013 May.

Artigo em Inglês | MEDLINE | ID: mdl-23420491

17.

Activation of the pyrin inflammasome by intracellular Burkholderia cenocepacia.

Gavrilin, Mikhail A; Abdelaziz, Dalia H A; Mostafa, Mahmoud; Abdulrahman, Basant A; Grandhi, Jaykumar; Akhter, Anwari; Abu Khweek, Arwa; Aubert, Daniel F; Valvano, Miguel A; Wewers, Mark D; Amer, Amal O.

J Immunol ; 188(7): 3469-77, 2012 Apr 01.

Artigo em Inglês | MEDLINE | ID: mdl-22368275

18.

The Septin Cytoskeleton is Required for Plasma Membrane Repair.

Prislusky, M Isabella; Lam, Jonathan Gt; Contreras, Viviana Ruiz; Ng, Marilynn; Chamberlain, Madeline; Pathak-Sharma, Sarika; Fields, Madalyn; Zhang, Xiaoli; Amer, Amal O; Seveau, Stephanie.

bioRxiv ; 2024 Jan 06.

Artigo em Inglês | MEDLINE | ID: mdl-37503091

19.

Gasdermin D promotes influenza virus-induced mortality through neutrophil amplification of inflammation.

Speaks, Samuel; McFadden, Matthew I; Zani, Ashley; Solstad, Abigail; Leumi, Steve; Roettger, Jack E; Kenney, Adam D; Bone, Hannah; Zhang, Lizhi; Denz, Parker J; Eddy, Adrian C; Amer, Amal O; Robinson, Richard T; Cai, Chuanxi; Ma, Jianjie; Hemann, Emily A; Forero, Adriana; Yount, Jacob S.

Nat Commun ; 15(1): 2751, 2024 Mar 29.

Artigo em Inglês | MEDLINE | ID: mdl-38553499

20.

DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates inflammation and amyloid-ß deposition in Alzheimer's disease.

Daily, Kylene P; Badr, Asmaa; Eltobgy, Mostafa; Estfanous, Shady; Whitham, Owen; Tan, Michelle H; Carafice, Cierra; Krause, Kathrin; McNamara, Andrew; Hamilton, Kaitlin; Houle, Samuel; Gupta, Spandan; Gupta, Gauruv A; Madhu, Shruthi; Fitzgerald, Julie; Saadey, Abbey A; Laster, Brooke; Yan, Pearlly; Webb, Amy; Zhang, Xiaoli; Pietrzak, Maciej; Kokiko-Cochran, Olga N; Ghoneim, Hazem E; Amer, Amal O.

Alzheimers Res Ther ; 16(1): 29, 2024 02 08.

Artigo em Inglês | MEDLINE | ID: mdl-38326859

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